Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

被引：109

作者：

Gomes, Ana R. ^{[1
]}

Zhao, Fung ^{[1
]}

Lam, Eric W. F. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London W12 0NN, England

来源：

CHINESE JOURNAL OF CANCER | 2013年 / 32卷 / 07期

关键词：

FOXO3a; FOXM1; transcription factor; cancer; drug resistance; tumorigenesis; BREAST-CANCER; GEFITINIB IRESSA; ER-ALPHA; EXPRESSION; TARGET; CELLS; IDENTIFICATION; MICROARRAY; CISPLATIN; APOPTOSIS;

D O I：

10.5732/cjc.012.10277

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.

引用

页码：365 / 370

页数：6

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