The role of beta- and alpha-adrenoreceptors on blood flow and temperature of brown adipose tissue and involvement of nitric oxide in their effects

被引：5

作者：

Nagashima, T ^{[1
]}

Kuroshima, A ^{[1
]}

Yoshida, T ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT INTERNAL MED 1,KYOTO 602,JAPAN

来源：

JOURNAL OF THERMAL BIOLOGY | 1996年 / 21卷 / 5-6期

关键词：

brown adipose tissue; blood flow; temperature; adrenoreceptor; nitric oxide;

D O I：

10.1016/S0306-4565(96)00011-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

1. Isoproterenol increased interscapular brown adipose tissue (BAT) blood flow and temperature. 2. Phenylephrine increased BAT temperature, but did not affect blood flow. The effect was completely suppressed by N-omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of endogenous NO synthesis. 3. Isoproterenol plus phenylephrine increased BAT blood flow and temperature earlier than isoproterenol alone. 4. CL316,243 increased BAT blood flow and temperature. These effects were also inhibited by L-NAME. 5. These data suggest that BAT blood flow as well as thermogenesis is regulated mainly by beta-adrenoreceptors and partly by alpha(1)-adrenoreceptors, and NO may be a common mediator for their regulations. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：313 / 318

页数：6

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