Effects of Inhibitory rTMS on Bladder Function in Parkinson's Disease Patients

被引：51

作者：

Brusa, Livia ^{[2
]}

Agro, Enrico Finazzi ^{[3
]}

Petta, Filomena ^{[3
]}

Sciobica, Francesco ^{[3
]}

Torriero, Sara ^{[4
]}

Lo Gerfo, Emanuele ^{[4
]}

Lani, Cesare ^{[2
]}

Stanzione, Paolo ^{[1
,4
]}

Koch, Giacomo ^{[1
,4
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy

[2] Osped S Eugenio, UOC Neurol, Rome, Italy

[3] Univ Roma Tor Vergata, Urol Clin, I-00133 Rome, Italy

[4] Fdn Santa Lucia IRCCS, Rome, Italy

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 03期

关键词：

bladder functions; transcranial magnetic stimulation; Parkinson's disease; rTMS; urodynamic; TRANSCRANIAL MAGNETIC STIMULATION; SUBTHALAMIC STIMULATION; URINARY-BLADDER; DYSFUNCTION;

D O I：

10.1002/mds.22434

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Patients affected by Parkinson's disease (PD) may present with lower urinary tract (LUT) dysfunction characterized by involuntary detrusor overactivity. We evaluated possible impact of a 2-week course of low frequency 1 Hz repetitive transcranial magnetic stimulation (rTMS) on LUT behavior in eight advanced PI) patients complaining of urinary disturbances. We tested the effects of rTMS measuring urodynamic examination and the International Prostate Symptoms Score (IPSS) questionnaire, used for evaluation of subjective LUTS. rTMS was able to improve temporarily LUT behavior in PD patients, increasing bladder capacity and the first sensation of filling phase. Moreover, a reduction of IPSS score was noticed, due to an improvement on filling phase symptoms. The beneficial effects assessed with the IPSS lasted for up to 2 weeks after the end of the stimulation. rTMS seems to be an effective, noninvasive alternative treatment for PD patients with urinary disturbances. (C) 2009 Movement Disorder Society

引用

页码：445 / 448

页数：4

共 12 条

[1]

Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052

[2]

Acute vs chronic effects of L-dopa on bladder function in patients with mild Parkinson disease [J].

Brusa, L. ;

Petta, F. ;

Pisani, A. ;

Moschella, V. ;

Iani, C. ;

Stanzione, P. ;

Miano, R. ;

Finazzi-Agro, E. .

NEUROLOGY, 2007, 68 (18) :1455-1459

[3]

Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis [J].

Centonze, D. ;

Petta, F. ;

Versace, V. ;

Rossi, S. ;

Torelli, F. ;

Prosperetti, C. ;

Rossi, St ;

Marfia, G. A. ;

Bernardi, G. ;

Koch, G. ;

Miano, R. ;

Boffa, L. ;

Finazzi-Agro, E. .

MULTIPLE SCLEROSIS, 2007, 13 (02) :269-271

[4]

Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].

Chen, R ;

Classen, J ;

Gerloff, C ;

Celnik, P ;

Wassermann, EM ;

Hallett, M ;

Cohen, LG .

NEUROLOGY, 1997, 48 (05) :1398-1403

[5]

Clinical applications of transcranial magnetic stimulation in patients with movement disorders [J].

Edwards, Mark J. ;

Talelli, Penelope ;

Rothwell, John C. .

LANCET NEUROLOGY, 2008, 7 (09) :827-840

[6]

HATTORI T, 1992, JPN J PSYCHIAT NEUR, V46, P181

[7]

Improved sensory gating of urinary bladder afferents in Parkinsons disease following subthalamic stimulation [J].

Herzog, Jan ;

Weiss, Peter H. ;

Assmus, Ann ;

Wefer, Bjorn ;

Seif, Christoph ;

Braun, Peter M. ;

Pinsker, Marcus O. ;

Herzog, Hans ;

Volkmann, Jens ;

Deuschl, Gunther ;

Fink, Gereon R. .

BRAIN, 2008, 131 :132-145

[8]

Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease [J].

Herzog, Jan ;

Weiss, Peter H. ;

Assmus, Ann ;

Wefer, Bjoern ;

Seif, Christoph ;

Braun, Peter M. ;

Herzog, Hans ;

Volkmann, Jens ;

Deuschl, Guenther ;

Fink, Gereon R. .

BRAIN, 2006, 129 :3366-3375

[9]

ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[10]

Cerebral activation during micturition in normal men [J].

Nour, S ;

Svarer, C ;

Kristensen, JKI ;

Paulson, OB ;

Law, I .

BRAIN, 2000, 123 :781-789

← 1 2 →