Treatment of cancer with cryochemotherapy

被引：58

作者：

Mir, LM

Rubinsky, B

机构：

[1] Inst Gustave Roussy, CNRS, FRE 2530, F-94805 Villejuif, France

[2] Univ Calif Berkeley, Dept Biomed Engn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 86卷 / 10期

关键词：

cryosurgery; frozen tissues; bleomycin;

D O I：

10.1038/sj.bjc.6600306

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cryosurgery employs freezing to destroy solid tumours, However, frozen cells can survive and cause cancer recurrence, Bleomycin, an anticancer drug with a huge intrinsic cytotoxicity is normally not very effective because it is nonpermeant. We report that freezing facilitates bleomycin penetration into cells making it toxic to cryosurgery surviving cells at concentrations that are non-toxic systemically.

引用

页码：1658 / 1660

页数：3

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