Early pathologic and biochemical changes in Creutzfeldt-Jakob disease: Study of brain biopsies

被引：33

作者：

Castellani, R ^{[1
]}

Parchi, P ^{[1
]}

Stahl, J ^{[1
]}

Capellari, S ^{[1
]}

Cohen, M ^{[1
]}

Gambetti, P ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT NEUROL,CLEVELAND,OH 44106

来源：

NEUROLOGY | 1996年 / 46卷 / 06期

关键词：

D O I：

10.1212/WNL.46.6.1690

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined brain biopsy tissue fi om five patients with a neurologic syndrome consistent with Creutzfeldt-Jakob disease using Western blot analysis and immunohistochemistry for the detection of protease-resistant prion protein, in addition to histopathologic examination. Our results indicate that the formation of protease-resistant prion protein is an early event in disease pathogenesis and Western blot analysis can detect protease-resistant prion protein in the absence of structural lesions using a small amount of brain biopsy tissue.

引用

页码：1690 / 1693

页数：4

共 10 条

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