Structure/function of α-synuclein in health and disease:: rational development of animal models for Parkinson's and related diseases

被引：71

作者：

Kahle, PJ

Haass, C

Kretzschmar, HA

Neumann, M

机构：

[1] Univ Munich, Dept Biochem, Lab Alzheimers & Parkinsons Dis Res, D-80336 Munich, Germany

[2] Univ Munich, Dept Neuropathol, D-80336 Munich, Germany

来源：

JOURNAL OF NEUROCHEMISTRY | 2002年 / 82卷 / 03期

关键词：

D O I：

10.1046/j.1471-4159.2002.01020.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：449 / 457

页数：9

共 102 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].

Abeliovich, A ;

Schmitz, Y ;

Fariñas, I ;

Choi-Lundberg, D ;

Ho, WH ;

Castillo, PE ;

Shinsky, N ;

Verdugo, JMG ;

Armanini, M ;

Ryan, A ;

Hynes, M ;

Phillips, H ;

Sulzer, D ;

Rosenthal, A .

NEURON, 2000, 25 (01) :239-252

[2] α-Synuclein and the Parkinson's disease-related mutant Ala53Thr-α-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells [J].

Ancolio, K ;

da Costa, CA ;

Uéda, K ;

Checler, F .

NEUROSCIENCE LETTERS, 2000, 285 (02) :79-82

[3] Pure autonomic failure in association with human α-synucleinopathy [J].

Arai, K ;

Kato, N ;

Kashiwado, K ;

Hattori, T .

NEUROSCIENCE LETTERS, 2000, 296 (2-3) :171-173

[4] Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein [J].

Arawaka, S ;

Saito, Y ;

Murayama, S ;

Mori, H .

NEUROLOGY, 1998, 51 (03) :887-889

[5]

Baba M, 1998, AM J PATHOL, V152, P879

[6] α-Synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease β-amyloid plaque cores [J].

Bayer, TA ;

Jäkälä, P ;

Hartmann, T ;

Havas, L ;

McLean, C ;

Culvenor, JG ;

Li, QX ;

Masters, CL ;

Falkai, P ;

Beyreuther, K .

NEUROSCIENCE LETTERS, 1999, 266 (03) :213-216

[7] Impairment of the ubiquitin-proteasome system by protein aggregation [J].

Bence, NF ;

Sampat, RM ;

Kopito, RR .

SCIENCE, 2001, 292 (5521) :1552-1555

[8] Degradation of α-synuclein by proteasome [J].

Bennett, MC ;

Bishop, JF ;

Leng, Y ;

Chock, PB ;

Chase, TN ;

Mouradian, MM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (48) :33855-33858

[9] Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].

Betarbet, R ;

Sherer, TB ;

MacKenzie, G ;

Garcia-Osuna, M ;

Panov, AV ;

Greenamyre, JT .

NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306

[10] Residual structure and dynamics in Parkinson's disease-associated mutants of α-synuclein [J].

Bussell, R ;

Eliezer, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (49) :45996-46003

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