Bioavailability in effect-directed analysis of organic toxicants in sediments

被引：43

作者：

Brack, Werner ^{[1
]}

Bandow, Nicole ^{[1
]}

Schwab, Katrin ^{[1
]}

Schulze, Tobias ^{[1
]}

Streck, Georg ^{[1
]}

机构：

[1] UFZ Helmholtz Ctr Environm Res, Helmholtz Ctr Environm Res, Dept Effect Directed Anal, D-04318 Leipzig, Germany

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2009年 / 28卷 / 05期

关键词：

Bioaccessibility-directed extraction; Bioavailability; Cyclodextrin; Effect-directed analysis; Organic toxicant; Partition-based dosing; Sediment; Silicone rod; TENAX; Toxicity; POLYCYCLIC AROMATIC-HYDROCARBONS; SOLID-PHASE MICROEXTRACTION; PARTITION-CONTROLLED DELIVERY; PREDICT BIOAVAILABILITY; TOXICITY IDENTIFICATION; CONTAMINATED SEDIMENT; SUBCRITICAL WATER; PAH AVAILABILITY; TENAX EXTRACTION; COMPLEX-MIXTURES;

D O I：

10.1016/j.trac.2009.02.010

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ignoring bioavailability in effect-directed analysis (EDA) of sediments may bias prioritization of toxic fractions and compounds towards lipophilic toxic fractions, which are hardly bioavailable. While EDA in benthic organisms is limited to answering specific questions, bioaccessibility-directed extraction (BIDE) appears generally applicable as a first step in sediment EDA. However, big differences in the efficiency of such extraction methods suggest the need for standardized criteria to simulate bioaccessibility. The most promising approach to simulate desorption and partitioning and thus bioavailability in sediments may be to combine BDE with partition-based dosing techniques. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：543 / 549

页数：7

共 53 条

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