Polyamidoamine Starburst® dendrimers as solubility enhancers

被引：175

作者：

Milhem, OM

Myles, C

McKeown, NB

Attwood, D

D'Emanuele, A ^{[1
]}

机构：

[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

[3] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 197卷 / 1-2期

关键词：

dendrimers; solubility enhancement; PAMAM G4 dendrimer; ibuprofen;

D O I：

10.1016/S0378-5173(99)00463-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：239 / 241

页数：3

共 6 条

[1] DAVIS LJ, 1975, DRUG INTEL CLIN PHAR, V9, P501
[2] Duncan R, 1996, P INT S CONTR REL BI, V23, P105
[3] Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers
KukowskaLatallo, JF
Bielinska, AU
Johnson, J
Spindler, R
Tomalia, DA
Baker, JR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) : 4897 - 4902
[4] CHEMISTRY OF MICELLES .13. UNIMOLECULAR MICELLES
NEWKOME, GR
MOOREFIELD, CN
BAKER, GR
SAUNDERS, MJ
GROSSMAN, SH
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (09): : 1178 - 1180
[5] A NEW CLASS OF POLYMERS - STARBURST-DENDRITIC MACROMOLECULES
TOMALIA, DA
BAKER, H
DEWALD, J
HALL, M
KALLOS, G
MARTIN, S
ROECK, J
RYDER, J
SMITH, P
[J]. POLYMER JOURNAL, 1985, 17 (01) : 117 - 132
[6] TOMALIA DA, 1995, SCI AM, V272, P42

← 1 →