Epigenetics in esophageal cancers

被引：52

作者：

Ahrens, Theresa D. ^{[1
,2
]}

Werner, Martin ^{[1
,3
,4
,5
]}

Lassmann, Silke ^{[1
,3
,4
,5
,6
,7
]}

机构：

[1] Univ Med Ctr, Dept Pathol, Freiburg, Germany

[2] Univ Freiburg, Fac Biol, D-79106 Freiburg, Germany

[3] Univ Med Ctr, Comprehens Canc Ctr Freiburg, Freiburg, Germany

[4] German Consortium Translat Canc Res DKTK, Heidelberg, Germany

[5] German Canc Res Ctr, Heidelberg, Germany

[6] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany

[7] Univ Freiburg Klinikum, Dept Pathol, Inst Klin Pathol, D-79106 Freiburg, Germany

来源：

CELL AND TISSUE RESEARCH | 2014年 / 356卷 / 03期

关键词：

Esophageal cancers; Epigenetics; miRNA; DNA Methylation; Histone marks; SQUAMOUS-CELL CARCINOMA; MICRORNA EXPRESSION; DNA METHYLATION; LINE-1; HYPOMETHYLATION; BARRETTS-ESOPHAGUS; APOPTOSIS; GROWTH; ADENOCARCINOMA; INHIBITORS; SIGNATURE;

D O I：

10.1007/s00441-014-1876-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Esophageal cancers are a challenging upper gastrointestinal tract tumor entity for interdisciplinary oncology. For the two main histotypes, namely esophageal squamous cell carcinomas and Barrett's adenocarcinomas, several genetic aberrations have been shown to contribute to carcinogenesis and progression as well as to represent potential novel targets for therapeutic intervention. This is paralleled by growing insight into epigenetic alterations of esophageal cancers. Studies involving the analyses of human tissue specimens predominantly describe altered patterns of miRNA expression, DNA methylation patterns, and histone marks levels. This review provides a critical update on this increasing knowledge of epigenetic alteration in esophageal cancers by specifically focusing on the translational aspects of epigenetic analyses from human tissue specimens.

引用

页码：643 / 655

页数：13

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