Ultra-short echo time spectroscopic imaging in rats:: implications for monitoring lipids in glioma gene therapy

被引：12

作者：

Liimatainen, Timo

Hakumaeki, Juhana

Tkac, Ivan

Groehn, Olli

机构：

[1] Univ Kuopio, AI Virtanen Inst Mol Sci, Dept Biomed NMR, FIN-70211 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Clin Radiol, SF-70210 Kuopio, Finland

[3] Univ Minneapolis, Ctr Magnet Resonance, Minneapolis, MN USA

来源：

NMR IN BIOMEDICINE | 2006年 / 19卷 / 05期

关键词：

spectroscopic imaging; short echo time; lipids; STEAM;

D O I：

10.1002/nbm.1031

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and prelocalization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method. Copyright (C) 2006 John Wiley & Sons, Ltd.

引用

收藏

页码：554 / 559

页数：6

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