学术探索
学术期刊
新闻热点
数据分析
智能评审

Essential elements as early indicators of hexavalent chromium nephrotoxicity

被引：14
作者：
Chmielnicka, J
Swietlicka, E
Nasiadek, M
机构：
[1] Med Univ Lodz, Sch Pharm, Dept Toxicol Chem, PL-90151 Lodz, Poland
[2] Washington Univ, Sch Med, Dept Gastroenterol, St Louis, MO USA
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2002年 / 53卷 / 01期
关键词：
nephrotoxicity; chromium; rats; zinc; copper; essential elements;
D O I：
10.1006/eesa.2001.2152
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The kidney is the appropriate critical organ for indicating chronic exposure to chromium compounds. The present work investigates the effect of dose-dependent hexavalent chromium concentration in various tissues of rats, the disturbances in metabolism of zinc and copper in liver and kidney, and histopathological changes in kidneys. White Wistar rats were used. Animals were injected intraperitoneally at a dose of 0.5 and 5 mg Cr/kg as K2CrO4. The animals were sacrificed after single and repeated doses at 24 h after the last injection. Disturbances in the metabolism of zinc and copper in the kidney of rats occur when the concentration of chromium in this organ attains about 30 mug Cr/g. An increase in urinary output of these essential metals is a more sensitive indicator of nephrotoxicity than ultrastructural damage of kidney. (C) 2002 Elsevier Science (USA).
引用
收藏
页码：20 / 26
页数：7
相关论文
共 31 条
[1]  
BOGDEN ID, 1980, ENVIRON RES, V217, P350
[2]   TISSUE DISPOSITION AND URINARY-EXCRETION OF CADMIUM, ZINC, COPPER AND IRON, FOLLOWING REPEATED PARENTERAL ADMINISTRATION OF CADMIUM TO RATS [J].
BONNER, FW ;
KING, LJ ;
PARKE, DV .
CHEMICO-BIOLOGICAL INTERACTIONS, 1979, 27 (2-3) :343-351
[3]   INTERACTION OF ALKYLMERCURIC COMPOUNDS WITH SODIUM SELENITE .1. METABOLISM OF ETHYLMERCURIC CHLORIDE ADMINISTERED ALONE AND IN COMBINATION WITH SODIUM SELENITE IN RATS [J].
BRZEZNICKA, EA ;
CHMIELNICKA, J .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1981, 39 (JUN) :131-142
[4]   INTERACTION OF ALKYLMERCURIC COMPOUNDS WITH SODIUM SELENITE .2. METABOLISM OF METHYLMERCURIC CHLORIDE ADMINISTERED ALONE AND IN COMBINATION WITH SODIUM SELENITE IN RATS [J].
BRZEZNICKA, EA ;
CHMIELNICKA, J .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 60 (MAY) :411-421
[5]   INTERACTION OF ALKYLMERCURIC COMPOUNDS WITH SODIUM SELENITE .3. BIOTRANSFORMATION, LEVELS OF METALLOTHIONEIN-LIKE PROTEINS AND ENDOGENOUS COPPER IN SOME TISSUES OF RATS EXPOSED TO METHYL OR ETHYLMERCURIC CHLORIDE WITH AND WITHOUT SODIUM SELENITE [J].
BRZEZNICKA, EA ;
CHMIELNICKA, J .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 60 (MAY) :423-431
[6]   CHANGES IN CONCENTRATION OF ESSENTIAL METALS IN KIDNEYS AND URINE AS INDEXES OF GENTAMICIN-NEPHROTOXICITY IN FEMALE WISTAR RATS [J].
CHMIELNICKA, J ;
SZYMANSKA, JA ;
BRZEZNICKA, EA ;
KALUZYNSKI, A .
PHARMACOLOGY & TOXICOLOGY, 1992, 71 (03) :185-189
[7]  
CHMIELNICKA J, 1989, Journal of Trace Elements in Experimental Medicine, V2, P331
[8]   DISTRIBUTION OF TIN IN THE RAT AND DISTURBANCES IN THE METABOLISM OF ZINC AND COPPER DUE TO REPEATED EXPOSURE TO SNCL2 [J].
CHMIELNICKA, J ;
SZYMANSKA, JA ;
SNIEC, J .
ARCHIVES OF TOXICOLOGY, 1981, 47 (04) :263-268
[9]   DISTURBANCES IN THE METABOLISM OF ENDOGENOUS METALS (ZN AND CU) IN NICKEL-EXPOSED RATS [J].
CHMIELNICKA, J ;
SZYMANSKA, JA ;
TYFA, J .
ENVIRONMENTAL RESEARCH, 1982, 27 (01) :216-221
[10]   VARIATION OF THE LEVEL OF MERCURY AND METALLOTHIONEIN IN THE KIDNEYS AND LIVER OF RATS WITH TIME OF EXPOSURE TO SODIUM SELENITE [J].
CHMIELNICKA, J ;
KOMSTASZUMSKA, E .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1980, 2 (02) :109-120
1234