Inducible differentiation and apoptosis of the pre-B cell receptor-positive pre-B cell line

被引：15

作者：

Kato, I

Miyazaki, T

Nakamura, T

Kudo, A

机构：

[1] Tokyo Inst Technol, Dept Life Sci, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Infect Dis & Appl Immunol, Tokyo 1088639, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

apoptosis; gene rearrangement; pre-B cell receptor; surrogate light chain; tyrosine phosphorylation;

D O I：

10.1093/intimm/12.3.325

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The function of the pre-B cell receptor (pre-BCR) during a cell differentiation is not precisely defined. To investigate the pre-BCR receptor activity, we have established pre-BCR-positive pre-B cell lines that are able to differentiate into immature a cells in vitro. Antibody cross-linking of the pre-BCR induced apoptosis and differentiation accompanied with tyrosine phosphorylation. A specific tyrosine-phosphorylated 43 kDa protein (p43) was found down-stream of the pre-BCR. The results demonstrated the receptor function of pre-BCR, which indicates that a ligand-like molecule or a cross-linking structure on the cell surface is possibly present.

引用

页码：325 / 334

页数：10

共 44 条

[1] STRUCTURE AND PRE-B LYMPHOCYTE RESTRICTED EXPRESSION OF THE VPREB GENE IN HUMANS AND CONSERVATION OF ITS STRUCTURE IN OTHER MAMMALIAN-SPECIES [J].