Development and validation of a patient questionnaire to determine New York Heart Association classification

被引:84
作者
Kubo, SH
Schulman, S
Starling, RC
Jessup, M
Wentworth, D
Burkhoff, D
机构
[1] Acorn Cardiovasc Inc, St Paul, MN 55112 USA
[2] Johns Hopkins Univ, Dept Med, Baltimore, MD USA
[3] Cleveland Univ Fdn, Dept Cardiovasc Med, Kaufman Ctr Heart Failure, Cleveland, OH USA
[4] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[5] Columbia Univ, Dept Med, New York, NY USA
关键词
New York Heart Association; heart failure; functional class; questionnaires;
D O I
10.1016/j.cardfail.2003.10.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: New York Heart Association (NYHA) classification correlates with quality of life and is useful in tracking changes in status in clinical trials. We explored methods to determine NYHA class in multicenter trials where double-blind conditions could not be maintained. Methods and results: A questionnaire was developed containing 7 major questions based on the standard definitions of NYHA classes. The questionnaire was administered to 116 patients with varying degrees of heart failure. When comparing NYHA determined by physicians at the site to NYHA assigned by 3 independent physician graders, there was an approximate 60% concordance. Concordance between independent reviewers was approximately 75%. Results of repeat grading of 30 randomly selected questionnaires indicated that graders provided the same score 90% of the time. Thus, although there were some differences from the site determination of NYHA class, the questionnaire had good inter- and intragrader reproducibility. In a second group of 103 patients enrolled in an ongoing device-intervention trial, we demonstrated that it is feasible to employ the questionnaire in a multicenter trial. Finally, NYHA class was correlated with quality of life and peak exercise oxygen consumption. Conclusions: A standardized questionnaire provided an approximate 60% concordance in assigning NYHA classification compared to the site assessment with approximately 90% reproducibility. This approach may be useful to determine NYHA classification within the context of clinical trials where blinded conditions are not possible.
引用
收藏
页码:228 / 235
页数:8
相关论文
共 11 条
  • [1] Health-related quality of life measurement in heart failure: Challenges for the new millennium
    Al-Kaade, S
    Hauptman, PJ
    [J]. JOURNAL OF CARDIAC FAILURE, 2001, 7 (02) : 194 - 201
  • [2] Assessment of functional capacity in clinical and research applications -: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association
    Fleg, JL
    Piña, IL
    Balady, GJ
    Chaitman, BR
    Fletcher, B
    Lavie, C
    Limacher, MC
    Stein, RA
    Williams, M
    Bazzarre, T
    [J]. CIRCULATION, 2000, 102 (13) : 1591 - 1597
  • [3] EQUIVALENCE OF WEIGHTED KAPPA AND INTRACLASS CORRELATION COEFFICIENT AS MEASURES OF RELIABILITY
    FLEISS, JL
    COHEN, J
    [J]. EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT, 1973, 33 (03) : 613 - 619
  • [4] FRANCIS GS, 1989, CURR PROB CARDIOLOGY, V14, P631
  • [5] COMPARATIVE REPRODUCIBILITY AND VALIDITY OF SYSTEMS FOR ASSESSING CARDIOVASCULAR FUNCTIONAL CLASS - ADVANTAGES OF A NEW SPECIFIC ACTIVITY SCALE
    GOLDMAN, L
    HASHIMOTO, B
    COOK, EF
    LOSCALZO, A
    [J]. CIRCULATION, 1981, 64 (06) : 1227 - 1234
  • [6] Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: A new health status measure for heart failure
    Green, CP
    Porter, CB
    Bresnahan, DR
    Spertus, JA
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (05) : 1245 - 1255
  • [7] GUYATT GH, 1985, CAN MED ASSOC J, V132, P919
  • [8] Percutaneous transmyocardial laser revascularisation for severe angina: the PACIFIC randomised trial
    Oesterle, SN
    Sanborn, TA
    Ali, N
    Resar, J
    Ramee, SR
    Heuser, R
    Dean, L
    Knopf, W
    Schofield, P
    Schaer, GL
    Reeder, G
    Masden, R
    Yeung, AC
    Burkhoff, D
    [J]. LANCET, 2000, 356 (9243) : 1705 - 1710
  • [9] Rector TS, 1987, HEART FAILURE, V3, P198, DOI DOI 10.1177/1474515111435605
  • [10] CORRELATES AND PROGNOSTIC IMPLICATION OF EXERCISE CAPACITY IN CHRONIC CONGESTIVE HEART-FAILURE
    SZLACHCIC, J
    MASSIE, BM
    KRAMER, BL
    TOPIC, N
    TUBAU, J
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1985, 55 (08) : 1037 - 1042