5-HT modifiers as a potential treatment of asthma

被引：56

作者：

Cazzola, M

Matera, MG

机构：

[1] Cardarelli Hosp, Div Pneumol & Allergol, I-80121 Naples, Italy

[2] Cardarelli Hosp, Resp Clin Pharmacol Unit A, I-80121 Naples, Italy

[3] Second Univ, Sch Med, Inst Pharmacol & Toxicol, I-80135 Naples, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 01期

关键词：

D O I：

10.1016/S0165-6147(99)01408-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increased levels of free 5-HT have been shown to be present in the plasma of symptomatic asthmatic patients compared with levels in asymptomatic patients. In addition, free 5-HT has been shown to correlate positively with clinical status and negatively with pulmonary function. These findings suggest that 5-HT might play a role in the pathophysiology of acute asthma. Accordingly, modifiers of the 5-HT transmitter system such as compounds that affect the 5-HT transporter, prejunctional 5-HT receptors or postsynaptic 5-HT receptors might represent a novel treatment of asthma.

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页码：13 / 16

页数：4

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