Mitochondrial coenzyme Q content and aging

被引：62

作者：

Lass, A ^{[1
]}

Kwong, L ^{[1
]}

Sohal, RS ^{[1
]}

机构：

[1] So Methodist Univ, Dept Biol Sci, Dallas, TX 75275 USA

来源：

BIOFACTORS | 1999年 / 9卷 / 2-4期

关键词：

D O I：

10.1002/biof.5520090215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The main objective of this study was to determine the nature of the relationship between aging and mitochondrial coenzyme Q (CoQ) content. Mitochondria in the heart, skeletal muscle, kidney and brain of the mouse varied in both the amount of total CoQ (CoQ(9) + CoQ(10)) content as well as in the ratio of the CoQ(9) to CoQ(10). CoQ content declined with age only in the skeletal muscle. Caloric restriction (CR) resulted in an increase in the amount of CoQ(9) in skeletal muscle mitochondria. This effect was partially reversible upon termination of the caloric restriction regimen. Results suggest that a decrease in mitochondrial CoQ content is an integral aspect of aging in skeletal muscle.

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页码：199 / 205

页数：7

相关论文

共 31 条

[1] CHANGES IN ULTRASTRUCTURE AND RESPIRATORY CONTROL IN MITOCHONDRIA OF RAT HEART HYPERTROPHIED BY EXERCISE [J].

ARCOS, JC ;

SOHAL, RS ;

SUN, S ;

ARGUS, MF ;

BURCH, GE .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1968, 8 (01) :49-&

[2] COENZYME-Q CONTENT IN SYNAPTIC AND NONSYNAPTIC MITOCHONDRIA FROM DIFFERENT BRAIN-REGIONS IN THE AGING RAT [J].

BATTINO, M ;

GORINI, A ;

VILLA, RF ;

GENOVA, ML ;

BOVINA, C ;

SASSI, S ;

LITTARRU, GP ;

LENAZ, G .

MECHANISMS OF AGEING AND DEVELOPMENT, 1995, 78 (03) :173-187

[3] TISSUE COENZYME-Q (UBIQUINONE) AND PROTEIN CONCENTRATIONS OVER THE LIFE-SPAN OF THE LABORATORY RAT [J].

BEYER, RE ;

BURNETT, BA ;

CARTWRIGHT, KJ ;

EDINGTON, DW ;

FALZON, MJ ;

KREITMAN, KR ;

KUHN, TW ;

RAMP, BJ ;

RHEE, SY ;

ROSENWASSER, MJ ;

STEIN, M ;

AN, LCI .

MECHANISMS OF AGEING AND DEVELOPMENT, 1985, 32 (2-3) :267-281

[4] HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS [J].

CHANCE, B ;

SIES, H ;

BOVERIS, A .

PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :527-605

[5] EFFECT OF AGE ON THE FUNCTION OF MITOCHONDRIA ISOLATED FROM BRAIN AND HEART-TISSUE [J].

CHIU, YJD ;

RICHARDSON, A .

EXPERIMENTAL GERONTOLOGY, 1980, 15 (06) :511-517

[6]

CRANE FL, 1989, BIOCHIM BIOPHYS ACTA, V1000, P359

[7] EFFECT OF AGING ON THE OXIDATIVE-PHOSPHORYLATION PATHWAY [J].

DARNOLD, JR ;

VORBECK, ML ;

MARTIN, AP .

MECHANISMS OF AGEING AND DEVELOPMENT, 1990, 53 (02) :157-167

[8] UBIQUINONE, DOLICHOL, AND CHOLESTEROL-METABOLISM IN AGING AND ALZHEIMERS-DISEASE [J].

EDLUND, C ;

SODERBERG, M ;

KRISTENSSON, K ;

DALLNER, G .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1992, 70 (06) :422-428

[9] INHIBITION OF LIPID-PEROXIDATION BY UBIQUINOL IN SUBMITOCHONDRIAL PARTICLES IN THE ABSENCE OF VITAMIN-E [J].

FORSMARK, P ;

ABERG, F ;

NORLING, B ;

NORDENBRAND, K ;

DALLNER, G ;

ERNSTER, L .

FEBS LETTERS, 1991, 285 (01) :39-43

[10] MAJOR CHANGES IN COMPLEX-I ACTIVITY IN MITOCHONDRIA FROM AGED RATS MAY NOT BE DETECTED BY DIRECT ASSAY OF NADH-COENZYME-Q REDUCTASE [J].

GENOVA, ML ;

CASTELLUCCIO, C ;

FATO, R ;

CASTELLI, GP ;

PICH, MM ;

FORMIGGINI, G ;

BOVINA, C ;

MARCHETTI, M ;

LENAZ, G .

BIOCHEMICAL JOURNAL, 1995, 311 :105-109

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