In utero programming of cardiovascular disease

被引：286

作者：

Barker, DJP ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England

来源：

THERIOGENOLOGY | 2000年 / 53卷 / 02期

关键词：

fetal adaptation; undernutrition; post-natal health; insulin deficiency; hyper-tension;

D O I：

10.1016/S0093-691X(99)00258-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Low birth weight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished. These adaptations may be cardiovascular, metabolic or endocrine. They permanently change the structure and function of the body. Prevention of the diseases may depend on prevention of imbalances in fetal growth or imbalances between pre- and post-natal growth, or imbalances in nutrient supply to the fetus. (C) 1999 by Elsevier Science Inc.

引用

页码：555 / 574

页数：20

共 84 条

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