Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells

被引：14

作者：

Bruckert, F ^{[1
]}

Laurent, O ^{[1
]}

Satre, M ^{[1
]}

机构：

[1] Commissariat Energie Atom Grenoble, Dept Biol Mol & Struct, Lab Biochim & Biophys Syst Integres, CNRS,UMR 314, F-38054 Grenoble 9, France

来源：

PROTOPLASMA | 2000年 / 210卷 / 3-4期

关键词：

Rab7; protein; endocytosis; phagocytosis; lysosomal enzymes; cation-independent mannose 6-phosphate receptor;

D O I：

10.1007/BF01276850

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Small GTPases of the Rab subfamily localise to the cytoplasmic face of distinct membrane compartments and act as regulators of intracellular membrane traffic and transport vesicle formation. Among them. Rab7 controls the delivery of internalised material into degradative compartments and the acquisition of lysosomal hydrolases. This activity shapes the endocytic pathway of every cell type. In addition, this general role may adjust to serve specific needs in multicellular organisms.

引用

页码：108 / 116

页数：9

共 68 条

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