Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth

被引：225

作者：

Kottis, V

Thibault, P

Mikol, D

Xiao, ZC

Zhang, R

Dergham, P

Braun, PE ^{[1
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 176, Canada

[2] CNR, Inst Biol Sci, Ottawa, ON, Canada

[3] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

[4] Univ Montreal, Dept Pathol, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF NEUROCHEMISTRY | 2002年 / 82卷 / 06期

关键词：

arretin; myelin inhibitors; nerve regeneration; neurite outgrowth; OMgp;

D O I：

10.1046/j.1471-4159.2002.01146.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.

引用

页码：1566 / 1569

页数：4

共 22 条

[1] ANTIBODY AGAINST MYELIN-ASSOCIATED INHIBITOR OF NEURITE GROWTH NEUTRALIZES NONPERMISSIVE SUBSTRATE PROPERTIES OF CNS WHITE MATTER [J].