Calmodulin regulation (calmodulation) of voltage-gated calcium channels

被引：162

作者：

Ben-Johny, Manu ^{[1
,2
,3
,4
]}

Yue, David T. ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Calcium Signals Lab, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Ctr Cell Dynam, Baltimore, MD 21205 USA

来源：

JOURNAL OF GENERAL PHYSIOLOGY | 2014年 / 143卷 / 06期

基金：

美国国家卫生研究院;

关键词：

SOLUTION NMR STRUCTURE; CA2+ CHANNELS; CA2+-DEPENDENT INACTIVATION; DEPENDENT INACTIVATION; CA2+-SENSITIVE INACTIVATION; IQ DOMAIN; CRYSTAL-STRUCTURE; MEDIATED INACTIVATION; SYNAPTIC PLASTICITY; CA(V)1.3 CHANNELS;

D O I：

10.1085/jgp.201311153

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Calmodulin regulation (calmodulation) of the family of voltage-gated Ca(V)1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca2+ sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca2+ signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca2+ feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.

引用

页码：679 / 692

页数：14

共 119 条

[1]

Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel [J].

Adams, Paul J. ;

Rungta, Ravi L. ;

Garcia, Esperanza ;

van den Maagdenberg, Arn M. J. M. ;

MacVicar, Brian A. ;

Snutch, Terrance P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (43) :18694-18699

[2]

Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation [J].

Alseikhan, BA ;

DeMaria, CD ;

Colecraft, HM ;

Yue, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) :17185-17190

[3]

Rescuing a failing heart: think globally, treat locally [J].

Anderson, Mark E. ;

Mohler, Peter J. .

NATURE MEDICINE, 2009, 15 (01) :25-26

[4]

CALCIUM DEPENDENCE OF THE INACTIVATION OF CALCIUM CURRENTS IN SKELETAL-MUSCLE FIBERS OF AN INSECT [J].

ASHCROFT, FM ;

STANFIELD, PR .

SCIENCE, 1981, 213 (4504) :224-226

[5]

CHANNEL HANDS [J].

BABITCH, J .

NATURE, 1990, 346 (6282) :321-322

[6]

Continuously Tunable Ca2+ Regulation of RNA-Edited CaV1.3 Channels [J].

Bazzazi, Hojjat ;

Ben Johny, Manu ;

Adams, Paul J. ;

Soong, Tuck Wah ;

Yue, David T. .

CELL REPORTS, 2013, 5 (02) :367-377

[7]

Neurophysiology - Stressful pacemaking [J].

Bean, Bruce P. .

NATURE, 2007, 447 (7148) :1059-1060

[8]

BENJOHNY M, 2012, BIOPHYS J, V102, pA125

[9]

Calcium signaling and neurodegenerative diseases [J].

Bezprozvanny, Ilya .

TRENDS IN MOLECULAR MEDICINE, 2009, 15 (03) :89-100

[10]

Functional Properties of a Newly Identified C-terminal Splice Variant of Cav1.3 L-type Ca2+ Channels [J].

Bock, Gabriella ;

Gebhart, Mathias ;

Scharinger, Anja ;

Jangsangthong, Wanchana ;

Busquet, Perrine ;

Poggiani, Chiara ;

Sartori, Simone ;

Mangoni, Matteo E. ;

Sinnegger-Brauns, Martina J. ;

Herzig, Stefan ;

Striessnig, Joerg ;

Koschak, Alexandra .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (49) :42736-42748

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