Can PACAP-38 modulate immune and endocrine responses during lipopolysaccharide (LPS)-induced acute inflammation?

被引：7

作者：

Baranowska-Bik, Agnieszka ^{[1
]}

Bik, Wojciech ^{[1
]}

Wolinska-Witort, Ewa ^{[1
]}

Chmielowska, Magdalena ^{[1
]}

Martynska, Lidia ^{[1
]}

Baranowska, Boguslawa ^{[1
]}

机构：

[1] Med Ctr Postgrad Educ, Dept Neuroendocrinol, PL-01813 Warsaw, Poland

来源：

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY | 2006年 / 1070卷

关键词：

PACAP-38; immune system; endocrine system; acute inflammation;

D O I：

10.1196/annals.1317.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pituitary adenylate cyclase-activating polypeptide (PACAP) shows a potential anti-inflammatory activity and interacts with the endocrine system. The aim of the present article was to evaluate the effects of PACAP38 on the endocrine and immune systems during acute inflammation. Rats used in the experiments, divided into four groups, were given intraperitoneal injection of, respectively 0.9% NaCl, LPS, PACAP38, and LPS+PACAP38. Hormone (pituitary, adrenal, and thyroid) and cytokine (TNF-alpha, IL-6, H,10) concentrations were measured 2 and 4 h after the injection. Treatment with LPS + PACAP, as compared to LPS, caused TNF-alpha and corticosterone to decrease and T4 to increase after 2 h. These data suggest that PACAP modulates both the endocrine and immune responses in this model of septic shock.

引用

页码：156 / 160

页数：5

共 8 条

[1]

BASEDOWSKY HO, 1996, ENDOCR REV, V17, P64

[2]

Delgado M, 1999, J IMMUNOL, V162, P4685

[3]

Delgado M, 1999, J IMMUNOL, V162, P1707

[4] PACAP in immunity and inflammation [J].

Delgado, M ;

Abad, C ;

Martinez, C ;

Juarranz, MG ;

Leceta, J ;

Ganea, D ;

Gomariz, RP .

NEUROENDOCRINE AND NEURAL REGULATION OF AUTOIMMUNE AND INFLAMMATORY DISEASE: MOLECULAR, SYSTEMS, AND CLINICAL INSIGHTS, 2003, 992 :141-157

[5]

Delgado M, 1999, J IMMUNOL, V162, P1200

[6]

Ganea D, 2001, ARCH IMMUNOL THER EX, V49, P101

[7] The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily [J].

Sherwood, NM ;

Krueckl, SL ;

McRory, JE .

ENDOCRINE REVIEWS, 2000, 21 (06) :619-670

[8]

Vaudry D, 2000, PHARMACOL REV, V52, P269

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