Inhibitory effects of ascorbic acid and folinic acid on chromosome aberrations induced by pyrimethamine in vitro

被引：2

作者：

Egel, Q ^{[1
]}

Bilaloglu, R ^{[1
]}

Aydemir, N ^{[1
]}

机构：

[1] Univ Uludag, Fac Sci, Dept Biol, Gorukle, Turkey

来源：

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 2002年 / 22卷 / 05期

关键词：

ascorbic acid; folinic acid; pyrimethamine; chromosomal aberration; anticlastogen; protective effect;

D O I：

10.1002/tcm.10030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this study, the anticlastogenic effects of ascorbic acid and the protective effect of folinic acid against the formation of chromosomal aberrations in humans by pyrimethamine were investigated. Pyrimethamine is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. In this study, 18 different healthy people, who do not drink alcohol and are non-smokers, were chosen as an experimental group; 0.025 mg/ml pyrimethamine was given to the lymphocyte culture, which had been prepared with the peripheral blood taken from this group. After that each of the following doses were given to the same culture: 20, 40, and 80 mM of ascorbic acid and 25, 50, and 100 mM of folinic acid. The results of the cytogenetic evaluation showed that the aberrations due to pyrimethamine in the chromosomes were reduced by ascorbic acid and folinic acid significantly, depending on the given dose. (C) 2002 Wiley-Liss, Inc.

引用

页码：353 / 362

页数：10

共 37 条

[1]

THE EFFECT OF ANTIOXIDANTS ON BLEOMYCIN TREATMENT IN IN-VITRO AND IN-VIVO GENOTOXICITY ASSAYS [J].

ANDERSON, D ;

BASARAN, N ;

BLOWERS, SD ;

EDWARDS, AJ .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1995, 329 (01) :37-47

[2]

Antunes LMG, 1999, TERATOGEN CARCIN MUT, V19, P53

[3]

AYDEMIR N, 1996, J ENVIRON PATHOL TOX, V15, P78

[4]

Bijur GN, 1997, ENVIRON MOL MUTAGEN, V30, P339, DOI 10.1002/(SICI)1098-2280(1997)30:3&lt

[5]

339::AID-EM13&gt

[6]

3.0.CO

[7]

2-E

[8]

CHEN LH, 1988, ANTICANCER RES, V8, P739

[9]

CHEN M, 1994, TRANSPLANT P, V26, P3172

[10]

In vivo dominant lethal effect of pyrimethamine in male mouse germ cells [J].

Egeli, U ;

Aydemir, N ;

Akpmar, G ;

Çimen, Ç ;

Ergül, E ;

Tutar, G ;

Tunca, B ;

Bilaloglu, R .

MUTAGENESIS, 1999, 14 (01) :67-69

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