Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom
被引:4
作者:
Gandjbakhche, AH
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Gandjbakhche, AH
Chernomordik, V
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Chernomordik, V
Bonner, RF
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Bonner, RF
Hebden, JC
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Hebden, JC
Nossal, R
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Nossal, R
机构:
来源:
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE: THEORY, INSTRUMENTATION, MODEL, AND HUMAN STUDIES II, PROCEEDINGS OF
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1997年
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2979卷
关键词:
D O I:
10.1117/12.280246
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
The success of time-resolved imaging of an abnormal site embedded in thick tissue may rely on one's ability to quantify the absorption coefficient of the target as a specific spectroscopic signature. This task is particularly complicated when the scattering properties of the target differ from those of the surrounding tissue. Using data obtained from time-resolved transillumination experiments of abnormally absorbing and differentially scattering objects embedded in a tissue-like phantom, we show how a new deconvolution algorithm enables us to quantify the optical properties of the target. The algorithm is based on a photon random walk theory that expresses different time-dependent point spread functions to calculate the diffusive and absorptive contrasts obtained in time-of-flight measurements.