Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein

被引：221

作者：

Beasley, DWC

Barrett, ADT

机构：

[1] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

[2] WHO, Collaborating Ctr Trop Dis, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 24期

关键词：

D O I：

10.1128/JVI.76.24.13097-13100.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

引用

页码：13097 / 13100

页数：4

共 17 条

[1] Beasley DWC, 2001, ANN NY ACAD SCI, V951, P332
[2] Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype
Beasley, DWC
Li, L
Suderman, MT
Barrett, ADT
[J]. VIROLOGY, 2002, 296 (01) : 17 - 23
[3] Biophysical characterization and vector-specific antagonist activity of domain III of the tick-borne flavivirus envelope protein
Bhardwaj, S
Holbrook, M
Shope, RE
Barrett, ADT
Watowich, SJ
[J]. JOURNAL OF VIROLOGY, 2001, 75 (08) : 4002 - 4007
[4] NUCLEOTIDE CHANGES RESPONSIBLE FOR LOSS OF NEUROINVASIVENESS IN JAPANESE ENCEPHALITIS-VIRUS NEUTRALIZATION-RESISTANT MUTANTS
CECILIA, D
GOULD, EA
[J]. VIROLOGY, 1991, 181 (01) : 70 - 77
[5] West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness
Chambers, TJ
Halevy, M
Nestorowicz, A
Rice, CM
Lustig, S
[J]. JOURNAL OF GENERAL VIROLOGY, 1998, 79 : 2375 - 2380
[6] Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
Crill, WD
Roehrig, JT
[J]. JOURNAL OF VIROLOGY, 2001, 75 (16) : 7769 - 7773
[7] SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
Guex, N
Peitsch, MC
[J]. ELECTROPHORESIS, 1997, 18 (15) : 2714 - 2723
[8] Amino acid substitution(s) in the stem-anchor region of Langat virus envelope protein attenuates mouse neurovirulence
Holbrook, MR
Ni, H
Shope, RE
Barrett, ADT
[J]. VIROLOGY, 2001, 286 (01) : 54 - 61
[9] Genetic analysis of West Nile New York 1999 encephalitis virus
Jia, XY
Briese, T
Jordan, I
Rambaut, A
Chi, HC
Mackenzie, JS
Hall, RA
Scherret, J
Lipkin, WI
[J]. LANCET, 1999, 354 (9194) : 1971 - 1972
[10] Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
Lanciotti, RS
Roehrig, JT
Deubel, V
Smith, J
Parker, M
Steele, K
Crise, B
Volpe, KE
Crabtree, MB
Scherret, JH
Hall, RA
MacKenzie, JS
Cropp, CB
Panigrahy, B
Ostlund, E
Schmitt, B
Malkinson, M
Banet, C
Weissman, J
Komar, N
Savage, HM
Stone, W
McNamara, T
Gubler, DJ
[J]. SCIENCE, 1999, 286 (5448) : 2333 - 2337

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