Thoughts, behaviour, and brain dynamics during navigation in the real world

被引：273

作者：

Spiers, Hugo J. ^{[1
]}

Maguire, Eleanor A. ^{[1
]}

机构：

[1] UCL, Inst Neurol, Wellcome Dept Imaging Neurosci, London WC1N 3BG, England

来源：

NEUROIMAGE | 2006年 / 31卷 / 04期

基金：

英国惠康基金;

关键词：

SPATIAL NAVIGATION; PREFRONTAL CORTEX; HUMAN HIPPOCAMPUS; COGNITIVE MAPS; CAUDATE-NUCLEUS; FRONTAL-CORTEX; MEMORY; ROUTE; PLACE; REPRESENTATIONS;

D O I：

10.1016/j.neuroimage.2006.01.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

How does the human brain allow us to interact with and navigate through a constantly changing world? Whilst controlled experiments using functional brain imaging can give insightful snapshots of neuronal responses to relatively simplified stimuli, they cannot hope to mirror the challenges faced by the brain in the real world. However, trying to study the brain mechanisms supporting daily living represents a huge challenge. By combining functional neuroimaging, an accurate interactive virtual simulation of a bustling central London (UK), and a novel means of 'reading' participants' thoughts whilst they moved around the city, we ascertained the online neural correlates underpinning navigation in this real-world context. A complex choreography of neural dynamics was revealed comprising focal and distributed, transient and sustained brain activity. Our results provide new insights into the specific roles of individual brain areas, in particular the hippocampus, retrosplenial, and frontal cortices, as well as offering clues about how functional specialisations operate within dynamic brain systems. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1826 / 1840

页数：15

共 50 条

[1] The parahippocampus subserves topographical learning in man [J].

Aguirre, GK ;

Detre, JA ;

Alsop, DC ;

DEsposito, M .

CEREBRAL CORTEX, 1996, 6 (06) :823-829

[2] A hierarchy of associations in hippocampo-cortical systems: Cognitive maps and navigation strategies [J].

Banquet, JP ;

Gaussier, P ;

Quoy, M ;

Revel, A ;

Burnod, Y .

NEURAL COMPUTATION, 2005, 17 (06) :1339-1384

[3] Functional brain mapping during free viewing of natural scenes [J].

Bartels, A ;

Zeki, S .

HUMAN BRAIN MAPPING, 2004, 21 (02) :75-85

[4] Memory for events and their spatial context: models and experiments [J].

Burgess, N ;

Becker, S ;

King, JA ;

O'Keefe, J .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 356 (1413) :1493-1503

[5] The human hippocampus and spatial and episodic memory [J].

Burgess, N ;

Maguire, EA ;

O'Keefe, J .

NEURON, 2002, 35 (04) :625-641

[6]

Burgess N, 1996, HIPPOCAMPUS, V6, P749

[7] Head direction, place, and movement correlates for cells in the rat retrosplenial cortex [J].

Cho, JW ;

Sharp, PE .

BEHAVIORAL NEUROSCIENCE, 2001, 115 (01) :3-25

[8] Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning [J].

Corlett, PR ;

Aitken, MRF ;

Dickinson, A ;

Shanks, DR ;

Honey, GD ;

Honey, RAE ;

Robbins, TW ;

Bullmore, ET ;

Fletcher, PC .

NEURON, 2004, 44 (05) :877-888

[9] How do you feel? Interoception: the sense of the physiological condition of the body [J].

Craig, AD .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (08) :655-666

[10] Cellular networks underlying human spatial navigation [J].

Ekstrom, AD ;

Kahana, MJ ;

Caplan, JB ;

Fields, TA ;

Isham, EA ;

Newman, EL ;

Fried, I .

NATURE, 2003, 425 (6954) :184-187

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