Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

被引：126

作者：

Venkatesan, S. ^{[1
,2
]}

Rosenthal, R. ^{[1
]}

Kanu, N. ^{[1
]}

McGranahan, N. ^{[1
]}

Bartek, J. ^{[3
,4
,5
]}

Quezada, S. A. ^{[1
,6
]}

Hare, J. ^{[7
]}

Harris, R. S. ^{[8
,9
,10
,11
,12
]}

Swanton, C. ^{[1
,2
]}

机构：

[1] UCL Canc Inst, CRUK Lung Canc Ctr Excellence, London, England

[2] Francis Crick Inst, Translat Canc Therapeut Lab, 1 Midland Rd, London NW1 1AT, England

[3] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[4] Sci Life Lab, Stockholm, Sweden

[5] Karolinska Inst, Div Genome Biol, Dept Biochem & Biophys, Stockholm, Sweden

[6] UCL Canc Inst, Canc Immunol Unit, London, England

[7] IAVI, New York, NY USA

[8] Masonic Canc Ctr, Minneapolis, MN USA

[9] Inst Mol Virol, Minneapolis, MN USA

[10] Ctr Genome Engn, Minneapolis, MN USA

[11] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA

[12] Univ Minnesota, Howard Hughes Med Inst, Minneapolis, MN 55455 USA

来源：

ANNALS OF ONCOLOGY | 2018年 / 29卷 / 03期

基金：

英国惠康基金; 美国国家卫生研究院; 新加坡国家研究基金会; 欧洲研究理事会; 英国医学研究理事会; 瑞典研究理事会;

关键词：

APOBEC; immune escape; drug resistance; human immunodeficiency virus; intratumour heterogeneity; DNA-DAMAGE RESPONSE; RNA EDITING ENZYME; MUTATIONAL PROCESSES; CCR5; ANTAGONIST; MESSENGER-RNA; CLONAL EVOLUTION; HYPERMUTATION; EXPRESSION; FAMILY; DEGRADATION;

D O I：

10.1093/annonc/mdy003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.

引用

页码：563 / 572

页数：10

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