Synthesis and peptide-induced degradation of biocompatible fibers based on highly branched poly(2-hydroxyethyl methacrylate)

被引：61

作者：

Wang, Linge ^{[1
]}

Li, Chengming ^{[1
]}

Ryan, Anthony J. ^{[1
]}

Armes, Steven P. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Brook Hill, Sheffield, S Yorkshire, England

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 12期

关键词：

D O I：

10.1002/adma.200600314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocomnatible fibers (see figure) are prepared by electrospinning branched poly(2-hydroxyethyl methacrylate) copolymers from methanol. These copolymers contain disulfide branch sites that can be cleaved using tripeptides such as glutathione. Cleavage reduces the copolymer molecular weight substantially, leading to complete fiber dissolution.

引用

页码：1566 / 1570

页数：5

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