共 93 条
Endosomal and non-endosomal functions of ESCRT proteins
被引:199
作者:

Slagsvold, Thomas
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机构: Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway

Pattni, Krupa
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机构: Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway

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Stenmark, Harald
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Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway
机构:
[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway
[2] Univ Oslo, N-0310 Oslo, Norway
关键词:
D O I:
10.1016/j.tcb.2006.04.004
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.
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页码:317 / 326
页数:10
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