Endosomal and non-endosomal functions of ESCRT proteins

被引:199
作者
Slagsvold, Thomas
Pattni, Krupa
Malerod, Lene
Stenmark, Harald [1 ]
机构
[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway
[2] Univ Oslo, N-0310 Oslo, Norway
关键词
D O I
10.1016/j.tcb.2006.04.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.
引用
收藏
页码:317 / 326
页数:10
相关论文
共 93 条
[1]   Ubiquitin interactions of NZF zinc fingers [J].
Alam, SL ;
Sun, J ;
Payne, M ;
Welch, BD ;
Blake, BK ;
Davis, DR ;
Meyer, HH ;
Emr, SD ;
Sundquist, WI .
EMBO JOURNAL, 2004, 23 (07) :1411-1421
[2]   The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways [J].
Amerik, AY ;
Nowak, J ;
Swaminathan, S ;
Hochstrasser, M .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (10) :3365-3380
[3]   Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding [J].
Amit, I ;
Yakir, L ;
Katz, M ;
Zwang, Y ;
Marmor, MD ;
Citri, A ;
Shtiegman, K ;
Alroy, I ;
Tuvia, S ;
Reiss, Y ;
Roubini, E ;
Cohen, M ;
Wides, R ;
Bacharach, E ;
Schubert, U ;
Yarden, Y .
GENES & DEVELOPMENT, 2004, 18 (14) :1737-1752
[4]   Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body [J].
Babst, M ;
Katzmann, DJ ;
Snyder, WB ;
Wendland, B ;
Emr, SD .
DEVELOPMENTAL CELL, 2002, 3 (02) :283-289
[5]   A protein's final ESCRT [J].
Babst, M .
TRAFFIC, 2005, 6 (01) :2-9
[6]   ESCRT-III: An endosome-associated heterooligomeric protein complex required for MVB sorting [J].
Babst, M ;
Katzmann, DJ ;
Estepa-Sabal, EJ ;
Meerloo, T ;
Emr, SD .
DEVELOPMENTAL CELL, 2002, 3 (02) :271-282
[7]   The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation [J].
Bache, KG ;
Slagsvold, T ;
Cabezas, A ;
Rosendal, KR ;
Raiborg, C ;
Stenmark, H .
MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (09) :4337-4346
[8]   Defective downregulation of receptor tyrosine kinases in cancer [J].
Bache, KG ;
Slagsvold, T ;
Stenmark, H .
EMBO JOURNAL, 2004, 23 (14) :2707-2712
[9]   Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes [J].
Bache, KG ;
Brech, A ;
Mehlum, A ;
Stenmark, H .
JOURNAL OF CELL BIOLOGY, 2003, 162 (03) :435-442
[10]   STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes [J].
Bache, KG ;
Raiborg, C ;
Mehlum, A ;
Stenmark, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) :12513-12521