Endosomal and non-endosomal functions of ESCRT proteins

被引：199

作者：

Slagsvold, Thomas

Pattni, Krupa

Malerod, Lene

Stenmark, Harald ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway

[2] Univ Oslo, N-0310 Oslo, Norway

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tcb.2006.04.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.

引用

收藏

页码：317 / 326

页数：10

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