Influence of phloretin on the skin permeation of lidocaine from semisolid preparations

被引：11

作者：

Auner, BG ^{[1
]}

Valenta, C ^{[1
]}

机构：

[1] Univ Vienna, Inst Pharmaceut Technol & Biopharmaceut, A-1090 Vienna, Austria

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2004年 / 57卷 / 02期

基金：

奥地利科学基金会;

关键词：

lidocaine; semisolid formulation; topical delivery; phloretin; permeation enhancer; porcine skin;

D O I：

10.1016/S0939-6411(03)00188-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of the present study was to determine the significance of phloretin on the topical permeation of lidocaine using different semisolid preparations as delivery systems. One hydrophilic and three lipophilic formulations were used. After estimation of the solubility of phloretin and lidocaine in the vehicles and analysis of the viscoelastic properties, standard diffusion experiments with Franz type diffusion cells through porcine skin were performed. Results indicate a general lidocaine enhancement by phloretin in the tested vehicles. The permeation was enhanced 1.39-fold in the hydrophilic formulation and between 1.25- and 1.76-fold in the lipophilic formulations. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：307 / 312

页数：6

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