The mechanism of the angiotensin-converting enzyme inhibitor quinapril is not related to bradykinin level in heart tissue

被引：3

作者：

Barthelemy, C ^{[1
]}

Eurin, J

Lechat, P

Masson, F

Cortines, M

Mougenot, N

Soualmia, H

Carayon, A

机构：

[1] CHU Pitie Salpetriere, Lab Biochim Med, F-75634 Paris 13, France

[2] CHU Pitie Salpetriere, Lab Pharmacol, IFR 14, F-75634 Paris, France

[3] CHU Pitie Salpetriere, Lab Ecole Prat Hautes Etudes, F-75634 Paris 13, France

来源：

PEPTIDES | 2002年 / 23卷 / 06期

关键词：

bradykinin; angiotensins; angiotensin-converting enzyme inhibition quinapril; heart; kidney; tissue distribution;

D O I：

10.1016/S0196-9781(02)00050-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In order to examine the effect of the angiotensin-converting enzyme inhibitor (ACEi) quinapril, we performed a sensitive and specific radioimmunoassay (RIA) to quantify bradykinin, BK-(1-9), in heart and kidney tissues. The BK-(1-9) level was unaffected in the heart of sham and water-deprived rats treated for 2 h with quinapril (10 mg/kg), but was significantly higher in the kidneys in the two groups. In these conditions, circulating and tissue angiotensin II (Ang II) levels were significantly decreased by quinapril. Moreover, our results indicated that acute treatment with this dose of quinapril induced kinin-mediated effects which were not related to its action on bradykinin degradation in rat hearts. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1161 / 1169

页数：9

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