Learning-specific decrease in synaptosomal ATP diphosphohydrolase activity from hippocampus and entorhinal cortex of adult rats

被引：27

作者：

Bonan, CD ^{[1
]}

Roesler, R ^{[1
]}

Pereira, GS ^{[1
]}

Battastini, AMO ^{[1
]}

Izquierdo, I ^{[1
]}

Sarkis, JJF ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil

来源：

BRAIN RESEARCH | 2000年 / 854卷 / 1-2期

关键词：

ATP diphosphohydrolase; apyrase; 5 '-nucleotidase; inhibitory avoidance; long-term potentiation; memory;

D O I：

10.1016/S0006-8993(99)02300-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Considering the involvement of extracellular ATP in the memory formation, we analyzed the effect of inhibitory avoidance training on ectonucleotidase activities in synaptosomes from hippocampus, entorhinal cortex and parietal cortex. ATP diphosphohydrolase activity presented a decrease (33%) in hippocampal synaptosomes of rats sacrificed 180 min after training. Our results also showed a decrease in synaptosomal ATP diphosphohydrolase (30% and 42% for ATP and ADP, respectively) in entorhinal cortex immediately after training. These findings suggest an integrated action of ATP diphosphohydrolase from hippocampus and entorhinal cortex in the formation of inhibitory avoidance memory. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：253 / 256

页数：4

共 19 条

[1] CHARACTERIZATION OF AN ATP DIPHOSPHOHYDROLASE (EC 3.6.1.5) IN SYNAPTOSOMES FROM CEREBRAL-CORTEX OF ADULT-RATS
BATTASTINI, AMO
DAROCHA, JBT
BARCELLOS, CK
DIAS, RD
SARKIS, JJF
[J]. NEUROCHEMICAL RESEARCH, 1991, 16 (12) : 1303 - 1310
[2] Inhibitory avoidance learning inhibits ectonucleotidases activities in hippocampal synaptosomes of adult rats
Bonan, CD
Dias, MM
Battastini, AMO
Dias, RD
Sarkis, JJF
[J]. NEUROCHEMICAL RESEARCH, 1998, 23 (07) : 977 - 982
[3] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4] A DIRECT COLORIMETRIC ASSAY FOR CA-2+-STIMULATED ATPASE ACTIVITY
CHAN, KM
DELFERT, D
JUNGER, KD
[J]. ANALYTICAL BIOCHEMISTRY, 1986, 157 (02) : 375 - 380
[5] Surface protein phosphorylation by ecto-protein kinase is required for the maintenance of hippocampal long-term potentiation
Chen, W
Wieraszko, A
Hogan, MV
Yang, HA
Kornecki, E
Ehrlich, YH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) : 8688 - 8693
[6] INTRAVENTRICULAR INFUSIONS OF ANTINEURAL CELL-ADHESION MOLECULES IN A DISCRETE POSTTRAINING PERIOD IMPAIR CONSOLIDATION OF A PASSIVE-AVOIDANCE RESPONSE IN THE RAT
DOYLE, E
NOLAN, PM
BELL, R
REGAN, CM
[J]. JOURNAL OF NEUROCHEMISTRY, 1992, 59 (04) : 1570 - 1573
[7] Demonstration of an extracellular ATP-binding site in NCAM: Functional implications of nucleotide binding
Dzhandzhugazyan, K
Bock, E
[J]. BIOCHEMISTRY, 1997, 36 (49) : 15381 - 15395
[8] SUBCELLULAR-LOCALIZATION OF 5'-NUCLEOTIDASE IN RAT-BRAIN
HEYMANN, D
REDDINGTON, M
KREUTZBERG, GW
[J]. JOURNAL OF NEUROCHEMISTRY, 1984, 43 (04) : 971 - 978
[9] Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats
Izquierdo, I
Quillfeldt, JA
Zanatta, MS
Quevedo, J
Schaeffer, E
Schmitz, PK
Medina, JH
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (04) : 786 - 793
[10] An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain
Kegel, B
Braun, N
Heine, P
Maliszewski, CR
Zimmermann, H
[J]. NEUROPHARMACOLOGY, 1997, 36 (09) : 1189 - 1200

← 1 2 →