Infrapopliteal balloon angioplasty for the treatment of chronic occlusive disease

被引:99
作者
Conrad, Mark F.
Kang, Jeanwan
Cambria, Richard P.
Brewster, David C.
Watkins, Michael T.
Kwolek, Christopher J.
LaMuraglia, Glenn M.
机构
[1] Massachusetts Gen Hosp, Gen Surg Serv, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
CRITICAL LIMB ISCHEMIA; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; LOWER-EXTREMITY REVASCULARIZATION; TIBIAL VESSEL OCCLUSIONS; SUBINTIMAL ANGIOPLASTY; RESULTS JUSTIFY; BARE STENTS; SALVAGE; ARTERIES; VEIN;
D O I
10.1016/j.jvs.2009.05.026
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: There is little documentation of the effectiveness of percutaneous balloon angioplasty (PTA) of infrapopliteal vessels for the treatment of chronic lower extremity ischemia. This stud), reviewed our recent experience with infrapopliteal PTA in a large series of patients to determine its effectiveness as a treatment modality. Methods: All patients undergoing primary infrapopliteal PTA from March 2002 to June 2006 were included. Primary study end points were primary patency, assisted patency, limb salvage, and patient survival assessed by Kaplan-Meier life-table analysis. Factors predictive of PTA failure and patient longevity were evaluated by multivariate methods. Results: There were 155 PTAs undertaken in 144 patients (70% men; mean age, 74 years), with critical limb ischemia (86%), diabetes (66%), and renal insufficiency (45%). Infrapopliteal lesions were classified as TransAtlantic Inter-Society Consensus A (7%), B (18%), C (39%), and D (35%). PTA was confined to the infrapopliteal segment in 40 (26%), and 115 (74%) underwent multilevel treatment. Five patients (3%) received stents. Technical success was 95%. The 30-day mortality was 2%, and major morbidity was 3%. The mean follow-up was 22 months (range, 0-54 months). The 40-month actuarial primary patency was 62% (standard error, 5%), with assisted patency (infrapopliteal re-PTA, 25 [16%]) of 90%. Interval conversion to bypass surgery occurred in seven (5%). Nonhealing ulcers occurred in 118 patients (76%), of which 76 (64%) healed during follow-up. Of the 42 unhealed ulcers, 15 (13%) required major amputations for a 40-month limb salvage of 86.2%. Multivariate predictors that were negative for primary patency included 0/1 vessel runoff (P = .01), critical limb ischemia (P = .002), and dialysis (P = .03). Negative predictors of limb salvage included dialysis (P = .007) and failure to improve runoff to the foot (P = .006). At 40-months, patient survival was 54%, with negative predictors including severe pulmonary disease (P = .01), coronary artery disease (P = .04), and renal insufficiency (P < .001). Conclusions: Infrapopliteal angioplasty can be performed safely with favorable results in patients with limited longevity. Primary patency is related to disease extent. Secondary interventions may be necessary to maintain clinical success. These data indicate that PTA should be considered as initial therapy for infrapopliteal occlusive disease in patients with lower extremity ischemia. (J Vasc Surg 2009;50:799-805.)
引用
收藏
页码:799 / 805
页数:7
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