Action of the saliva of Triatoma infestans (Heteroptera: Reduviidae) on sodium channels

被引：30

作者：

Dan, A

Pereira, MH

Pesquero, JL

Diotaiuti, L

Beirao, PSL

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil

[3] Ctr Pesquisas Rene Rachou Fiocruz, BR-30190002 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF MEDICAL ENTOMOLOGY | 1999年 / 36卷 / 06期

关键词：

Triatoma infestans; saliva; nervous conduction; Na+ channel;

D O I：

10.1093/jmedent/36.6.875

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Saliva of Triatoma infestans (Klug) produced a progressive reduction in the amplitude of the compound action potential recorded from rat sciatic nerve. The saliva also inhibited the Na+ current on GH(3) cells. The data demonstrate that the saliva of T. infestans has an inhibitory effect on Na+ channels. We conclude that this effect may decrease the generation and conduction of nerve action potential, thereby decreasing the sensitivity of the region in which the insect probes, in a manner similar to that of local anesthetics. This study demonstrates such activity in the saliva of hematophagous insects. The adaptive value of this activity is clear, because the quantity of blood obtained by triatomines is limited by the irritation caused during the feeding process.

引用

页码：875 / 879

页数：5

共 32 条

[1] Identification and characterization of a sialidase released by the salivary gland of the hematophagous insect Triatoma infestans [J].