Construction of heterocyclic compounds by use of α-diazophosphonates:: New one-pot syntheses of indoles and isocoumarins

被引:55
作者
Nakamura, Y [1 ]
Ukita, T [1 ]
机构
[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Osaka 5328505, Japan
关键词
D O I
10.1021/ol025916k
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] alpha-Diazophosphonates, which have extremely useful properties from a synthetic point of view, are disclosed as 1,1-ambiphilic one-carbon building blocks for one-pot construction of various heterocyclic compounds. They are easily prepared and have higher stability by the effect of the phosphoryl group than corresponding alpha-diazocarbonyl compounds. Using this synthon, we have developed a novel, mild, and efficient synthetic method of 2,3-disubstituted indoles and 3,4-disubstituted isocoumarins.
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页码:2317 / 2320
页数:4
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