Intranasal curcumin attenuates airway remodeling in murine model of chronic asthma

被引：61

作者：

Chauhan, Preeti S. ^{[1
]}

Subhashini ^{[1
]}

Dash, D. ^{[2
]}

Singh, Rashmi ^{[1
]}

机构：

[1] Banaras Hindu Univ, Dept Zool, MMV, Varanasi 221005, Uttar Pradesh, India

[2] Banaras Hindu Univ, Inst Med Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 21卷 / 01期

关键词：

Airway remodeling; Chronic asthma; Goblet cell; Inflammation; MESSENGER-RNA EXPRESSION; ALLERGIC INFLAMMATION; CELLS; HYPERRESPONSIVENESS; EOSINOPHILS; RECRUITMENT; MACROPHAGES; NEUTROPHIL; CHALLENGE; BLOCKADE;

D O I：

10.1016/j.intimp.2014.03.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Curcumin, phytochemical present in turmeric, rhizome of Curcuma longa, a known anti-inflammatory molecule with variety of pharmacological activities is found effective in murine model of chronic asthma characterized by structural alterations and airway remodeling. Here, we have investigated the effects of intranasal curcumin in chronic asthma where animals were exposed to allergen for longer time. In the present study Balb/c mice were sensitized by an intraperitoneal injection of ovalbumin (OVA) and subsequently challenged with 2% OVA in aerosol twice a week for five consecutive weeks. Intranasal curcumin (5 mg/kg) was administered from days 21 to 55, an hour before every nebulization and inflammatory cells recruitment, levels of IgE, EPO, IL-4 and IL-5 were found suppressed in bronchoalveolar lavage fluid (BALF). Intranasal curcumin administration prevented accumulation of inflammatory cells to the airways, structural alterations and remodeling associated with chronic asthma like peribronchial and airway smooth muscle thickening, sloughing off of the epithelial lining and mucus secretion in ovalbumin induced murine model of chronic asthma. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：63 / 75

页数：13

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