Integrated nanoreactor systems: Triggering the release and mixing of compounds inside single vesicles

被引：145

作者：

Bolinger, PY ^{[1
]}

Stamou, D ^{[1
]}

Vogel, H ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, LCPPM, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 28期

关键词：

D O I：

10.1021/ja049023u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a method that allows the on-demand release and mixing of zepto- to femtoliter volumes of solutions in the interior of vesicular nanoreactors. The reactors comprise a nested system of lipid vesicles, part of which release their cargo in the interior of the others during a thermotropic phase transition. The performance of individual reactors immobilized on glass is characterized using confocal microscopy and a fluorescent dye that reports dilution during the release. The results confirm the predicted temperature-induced response and reveal a release transition width of 3 °C with a half time of ∼1 min. Copyright © 2004 American Chemical Society.

引用

页码：8594 / 8595

页数：2

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