Complete coding regions of two novel HLA-B alleles detected by phototyping (PCR-SSP) in the British caucasoid population: B5108 and B5002

被引：12

作者：

Vilches, C

Bunce, M

dePablo, R

Murray, AK

McIntyre, CA

Kreisler, M

机构：

[1] CHURCHILL HOSP,OXFORD TRANSPLANT CTR,OXFORD OX3 7LJ,ENGLAND

[2] UNIV SHEFFIELD,SCH MED,INST CANC STUDIES,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

TISSUE ANTIGENS | 1997年 / 50卷 / 01期

关键词：

B*45; B*50; B*51; Cw*16027; HLA-B; new allele; nucleotide sequence; PCR-SSP;

D O I：

10.1111/j.1399-0039.1997.tb02831.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two previously reported PCR-SSP variants of the HLA-B locus, B51GAC and B45v, were investigated by RT-PCR cloning and nucleotide sequence analysis of their complete coding regions. They have been shown to correspond to the new alleles B*5108 and B*5002, both of which differ from the common B*5101 and B*5001 subtypes, respectively, by amino acid replacements at their alpha-2 domain alpha-helices. The primary structure of B*5002. intermediate between those of B*4501 and B*5001, raises further concern about the current classification of B*45 as a B12 rather than as a B*50 subtype.

引用

页码：38 / 41

页数：4

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Complete coding regions of two novel HLA-B alleles detected by phototyping (PCR-SSP) in the British caucasoid population: B*5108 and B*5002

Complete coding regions of two novel HLA-B alleles detected by phototyping (PCR-SSP) in the British caucasoid population: B5108 and B5002