CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection

被引：17

作者：

Bogers, WMJM

Bergmeier, LA

Oostermeijer, H

ten Haaft, P

Wang, Y

Kelly, CG

Singh, M

Heeney, JL

Lehner, T ^{[1
]}

机构：

[1] Guys Kings & St Thomas Hosp Med & Dent Sch, Dept Oral Med & Pathol, Mucosal Immunol Unit, London SE1 9RT, England

[2] Biomed Res Primate Ctr, Dept Virol, Rijswijk, Netherlands

[3] Lionex Diagnost & Therapeut GmbH, Braunschweig, Germany

来源：

VACCINE | 2004年 / 22卷 / 23-24期

关键词：

SIV; vaccine; CCR5;

D O I：

10.1016/j.vaccine.2004.02.050

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV We targeted the SIV CCR5 coreceptor in a combined CCR5-SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2974 / 2984

页数：11

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