Analysis of a paracentric inversion in human oocytes: nonhomologous pairing in pachytene

被引：20

作者：

Cheng, EY

Chen, YJ

Disteche, CM

Gartler, SM

机构：

[1] Univ Washington, Med Ctr, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[2] Univ Washington, Ctr Med, Dept Pathol, Washington, DC USA

[3] Washington Univ, Ctr Med, Dept Med & Genet, Washington, DC USA

来源：

HUMAN GENETICS | 1999年 / 105卷 / 03期

关键词：

D O I：

10.1007/s004399900120

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A cytological analysis of the pairing configurations in meiosis in a 19-week human fetus with a de novo paracentric inversion of chromosome 7 (q11.23)(q21.1) is reported, using fluorescent in situ hybridization with a chromosome 7 DNA library, a DNA probe for the centromeric region of chromosome 7, and a probe for the William Syndrome Critical Region (WSCR) at 7q11.23. Of 1079 pachytene cells. 58% exhibited complete heterosynapsis of the inverted region while only 10.3% of cells exhibited the expected loop formation. Meiotic progression was observed to be normal.

引用

页码：191 / 196

页数：6

共 36 条

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