CpRuIIPF6/quinaldic acid-catalyzed chemoselective allyl ether cleavage.: A simple and practical method for hydroxyl deprotection

被引：90

作者：

Tanaka, S

Saburi, H

Ishibashi, Y

Kitamura, M ^{[1
]}

机构：

[1] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Dept Chem, Nagoya, Aichi 4648602, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 11期

关键词：

D O I：

10.1021/ol0493397

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cationic CpRuII complex in combination with quinaldic acid shows high reactivity and chemoselectivity for the catalytic deprotection of hydroxyl groups protected as allyl ethers. The catalyst operates in alcoholic solvents without the need for any additional nucleophiles, satisfying the practical requirements of operational simplicity, safety, and environmental friendliness. The wide applicability of this deprotection strategy to a variety of multifunctional molecules, including peptides and nucleosides, may provide new opportunities in protective group chemistry.

引用

页码：1873 / 1875

页数：3

共 19 条

[1] REDUCTIVE DEPROTECTION OF ARYL ALLYL ETHERS WITH PD(PH3)(4)/NABH4 [J].