C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans

被引：506

作者：

Alvarez, CP

Lasala, F

Carrillo, J

Muñiz, O

Corbí, AL

Delgado, R ^{[1
]}

机构：

[1] Hosp 12 Octubre, Dept Microbiol, Mol Microbiol Lab, E-28041 Madrid, Spain

[2] CSIC, Ctr Invest Biol, E-28006 Madrid, Spain

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 13期

关键词：

D O I：

10.1128/JVI.76.13.6841-6844.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.

引用

页码：6841 / 6844

页数：4

共 18 条

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