Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy

被引：30

作者：

Harum, KH ^{[1
]}

Hoon, AH ^{[1
]}

Kato, GJ ^{[1
]}

Casella, JF ^{[1
]}

Breiter, SN ^{[1
]}

Johnston, MV ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

来源：

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | 1999年 / 41卷 / 11期

关键词：

D O I：

10.1017/S0012162299001541

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 5-year old girl with cerebral palsy (GP), preterm birth, postnatal aortic thrombus, and cerebellar venous infarction who is homozygous for the thrombophilic factor-V Leiden (fVL) mutation is reported. The role of hereditary thrombophilic disorders in the development of perinatal vascular lesions such as aortic thrombi, renal-vein thrombosis, venous-sinus thrombosis, and cerebral infarction is unknown. This case report brings into question a potential association between fVL, perinatal vascular lesions, perinatal stroke, and CP.

引用

页码：777 / 780

页数：4

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