Variation matters: TLR structure and species-specific pathogen recognition

被引：222

作者：

Werling, Dirk ^{[1
]}

Jann, Oliver C. ^{[2
,3
]}

Offord, Victoria ^{[1
]}

Glass, Elizabeth J. ^{[2
,3
]}

Coffey, Tracey J. ^{[4
]}

机构：

[1] Univ London Royal Vet Coll, Dept Pathol & Infect Dis, Hatfield AL9 7TA, Herts, England

[2] Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[3] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian, Scotland

[4] Inst Anim Hlth, Compton RG20 7NN, England

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 03期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

LEUCINE-RICH REPEATS; TOLL-LIKE RECEPTOR-4; GENE ARG753GLN POLYMORPHISM; INNATE IMMUNE-RESPONSES; CRYSTAL-STRUCTURE; BOVINE; LIGAND; LIPOPOLYSACCHARIDE; COMPLEX; INFECTION;

D O I：

10.1016/j.it.2008.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are an important link between innate and adaptive immunity. Many vaccines incorporate ligands for TLRs as an adjuvant and are developed in rodent models, with the resulting data transferred to other species. Vaccine features can be improved markedly by emphasizing the biological relevance when evaluating other animal models for host-pathogen interaction and by taking greater advantage of the unique experimental opportunities that are offered by large animal, non-rodent models. Here, we aim to summarize our current knowledge of species-specific TLR responses and briefly discuss that vaccine efficacy in relevant host species might be improved by considering the species-specific TLR responses.

引用

页码：124 / 130

页数：7

共 51 条

[1] Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition [J].