Thalidomide sensory neurotoxicity - A clinical and neurophysiologic study

被引：115

作者：

Cavaletti, G

Beronio, A

Reni, L

Ghiglione, E

Schenone, A

Briani, C

Zara, G

Cocito, D

Isoardo, G

Ciaramitaro, P

Plasmati, R

Pastorelli, F

Frigo, M

Piatti, M

Carpo, M

机构：

[1] Univ Milano Bicocca, Dipartimento & Tecnol Biomed, Monza, Italy

[2] Univ Genoa, Dipartimento Neurosci Oftalmol & Genet, Genoa, Italy

[3] Univ Genoa, Ctr Eccelenza Ric Biomed, Genoa, Italy

[4] Univ Padua, Dipartimento Neurosci, UO Neurofisiol Clin SC Neurol, I-35100 Padua, Italy

[5] Univ Turin, Dipartimento Neurosci, I-10124 Turin, Italy

[6] Univ Turin, Dipartimento Sci Neurol, I-10124 Turin, Italy

[7] Osped Bellaria Bologna, Neurol Clin, Unita Operat Neurol, Bologna, Italy

[8] AOS Gerardo, Monza, Italy

[9] Univ Milan, IRCCS Osped Maggiore Policlin, Dipartimento Sci Neurol, I-20122 Milan, Italy

来源：

NEUROLOGY | 2004年 / 62卷 / 12期

关键词：

D O I：

10.1212/WNL.62.12.2291

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high ( > 20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.

引用

页码：2291 / 2293

页数：3

共 10 条

[1] Incidence and risk factors for thalidomide neuropathy: a prospective study of 135 dermatologic patients [J].