Captive solvent [11C]acetate synthesis in GMP conditions

被引：30

作者：

Soloviev, Dmitri ^{[1
]}

Tamburella, Claire ^{[1
]}

机构：

[1] Univ Hosp Geneva, Cyclotron Unit, Unite Cyclotron, Serv Med Nucl,Dept Radiol & Informat Med, CH-1211 Geneva 14, Switzerland

来源：

APPLIED RADIATION AND ISOTOPES | 2006年 / 64卷 / 09期

关键词：

C-11]acetate; GMP; captive-solvent method; SPE purification;

D O I：

10.1016/j.apradiso.2006.04.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reliable procedure for the production of 1-[C-11]lacetate in GMP conditions was developed based on a combination of the captive-solvent Grignard reaction conducted in the sterile catheter followed by the convenient solid-phase extraction purification on a series of ion-exchange cartridges. The described procedure proved to be reliable in more than 30 patient productions. The process provides stable radiochemical yields (65% EOB) of sodium acetate (1-[C-11]) of the Ph.Eur. quality (radiochemical purity better than 95%) in a short time (5min). (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：995 / 1000

页数：6

共 18 条

[1]

ALBRECHT S, 2006, IN PRESS EUR J NUCL

[2] [C-11] ACETATE AND [C-11] ]METHIONINE - IMPROVED SYNTHESES AND QUALITY-CONTROL [J].