Activation of SoxR by overproduction of desulfoferrodoxin:: Multiple ways to induce the soxRS regulon

被引：18

作者：

Gaudu, P

Dubrac, S

Touati, D

机构：

[1] Univ Paris 06, CNRS, Inst Jacques Monod, F-75251 Paris 05, France

[2] Univ Paris 07, CNRS, Inst Jacques Monod, F-75251 Paris, France

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 06期

关键词：

D O I：

10.1128/JB.182.6.1761-1763.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The soxRS response, which protects cells against superoxide toxicity, is triggered by the oxidation of SoxR, a transcription factor. Superoxide excess and NADPH depletion induce the regulon. Unexpectedly, we found that the overproduction of desulfoferrodoxin, a superoxide reductase from sulfate-reducing bacteria, also induced this response. We suggest that desulfoferrodoxin interferes with the reducing pathway that keeps SoxR in its inactive form.

引用

页码：1761 / 1763

页数：3

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