Glycosidase mechanisms

被引：335

作者：

Vasella, A

Davies, GJ

Böhm, M

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

[2] Univ York, Dept Chem, Struct Biol Lab, York YO1 5DD, N Yorkshire, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(02)00380-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism, Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.

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页码：619 / 629

页数：11

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