Immunometabolism governs dendritic cell and macrophage function

被引：1327

作者：

O'Neill, Luke A. J. ^{[1
]}

Pearce, Edward J. ^{[2
]}

机构：

[1] Univ Dublin Trinity Coll, Trinity Biomed Sci, Sch Biochem & Immunol, Dublin 2, Ireland

[2] Max Planck Inst Immunobiol & Epigenet, Dept Immunometab, D-79108 Freiburg, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2016年 / 213卷 / 01期

基金：

爱尔兰科学基金会; 欧洲研究理事会;

关键词：

METABOLIC CHECKPOINT; NLRP3; INFLAMMASOME; ERR-ALPHA; ACTIVATION; RECEPTOR; RAPAMYCIN; GLYCOLYSIS; EXPRESSION; GLUCOSE; INNATE;

D O I：

10.1084/jem.20151570

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammatory diseases and cancer.

引用

页码：15 / 23

页数：9

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