Coupled heterocellular arrays in the brain

被引：12

作者：

Fróes, MM ^{[1
]}

Menezes, JRL ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Lab Neuroanat Celular, Dept Anat, Inst Ciencias Biomed, BR-21949900 Rio De Janeiro, Brazil

来源：

NEUROCHEMISTRY INTERNATIONAL | 2002年 / 41卷 / 05期

关键词：

gap junctions; CNS development; neuron; astrocyte; oligodendrocyte; neural precursors; electrical coupling; metabolic coupling; brain compartments; neuronal-glial interactions;

D O I：

10.1016/S0197-0186(02)00016-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gap junctions are transcellular pathways that enable a dynamic metabolic coupling and a selective exchange of biological signaling mediators. Throughout the course of the brain development these intercellular channels are assembled into regionally and temporally defined patterns. The present review summarizes the possibilities of heterocellular gap junctional pairing in the brain parenchyma, involving glial cells, neurons and neural precursors as well as it highlights on the meaningfulness of these coupled arrays to the concept of brain functional compartments. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：367 / 375

页数：9

共 140 条

[1] Growth hormone increases connexin-43 expression in the cerebral cortex and hypothalamus [J].