The kinome 'at large' in cancer

被引：219

作者：

Fleuren, Emmy D. G. ^{[1
]}

Zhang, Luxi ^{[2
,3
,4
]}

Wu, Jianmin ^{[5
]}

Daly, Roger J. ^{[2
,3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands

[2] Monash Univ, Biomed Discovery Inst, Canc Program, Clayton, Vic 3800, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[4] Univ New S Wales, Sydney, NSW 2052, Australia

[5] Garvan Inst Med Res, Kinghorn Canc Ctr, Canc Div, 370 Victoria St, Sydney, NSW 2010, Australia

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 02期

基金：

英国医学研究理事会;

关键词：

ACUTE MYELOID-LEUKEMIA; COMPREHENSIVE MOLECULAR CHARACTERIZATION; DNA-DAMAGE RESPONSE; CELL LUNG-CANCER; INTEGRATED GENOMIC CHARACTERIZATION; SYNTHETIC LETHAL INTERACTIONS; NEGATIVE BREAST-CANCER; PANCREATIC-CANCER; KINASE REQUIREMENTS; THERAPEUTIC TARGET;

D O I：

10.1038/nrc.2015.18

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome 'at large' in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

引用

页码：83 / 98

页数：16

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