Regulation of phosphate transport in proximal tubules

被引：135

作者：

Biber, J. ^{[1
,2
,3
]}

Hernando, N. ^{[2
,3
]}

Forster, I. ^{[2
,3
]}

Murer, H. ^{[2
,3
]}

机构：

[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

[3] Univ Zurich, Zurich Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 458卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Sodium-dependent cotransport; Phosphate homeostasis; Regulation; Phosphate excretion; COTRANSPORTER NAPI-IIA; P-I COTRANSPORTER; BRUSH-BORDER MEMBRANE; VITAMIN-D METABOLISM; FIBROBLAST GROWTH FACTOR-23; HEREDITARY HYPOPHOSPHATEMIC RICKETS; INDUCED DOWN-REGULATION; PARATHYROID-HORMONE; RENAL ADAPTATION; DIETARY PHOSPHATE;

D O I：

10.1007/s00424-008-0580-8

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Homeostasis of inorganic phosphate (P-i) is primarily an affair of the kidneys. Reabsorption of the bulk of filtered P-i occurs along the renal proximal tubule and is initiated by apically localized Na+-dependent P-i cotransporters. Tubular P-i reabsorption and therefore renal excretion of P-i is controlled by a number of hormones, including phosphatonins, and metabolic factors. In most cases, regulation of P-i reabsorption is achieved by changing the apical abundance of Na+/Pi cotransporters. The regulatory mechanisms involve various signaling pathways and a number of proteins that interact with Na+/P-i cotransporters.

引用

页码：39 / 52

页数：14

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